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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE2
All Species:
41.52
Human Site:
T141
Identified Species:
60.89
UniProt:
P56282
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56282
NP_002683.2
527
59537
T141
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Chimpanzee
Pan troglodytes
XP_509931
527
59578
T141
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Rhesus Macaque
Macaca mulatta
XP_001095940
525
59213
T144
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Dog
Lupus familis
XP_851216
527
59504
T141
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Cat
Felis silvestris
Mouse
Mus musculus
O54956
527
59368
T141
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Rat
Rattus norvegicus
XP_216727
527
59187
T141
Y
T
I
L
H
Q
R
T
H
R
H
E
L
F
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515002
535
60459
T149
Y
T
I
L
Q
Q
R
T
H
R
H
E
L
F
T
Chicken
Gallus gallus
Q5ZKQ6
527
59609
T141
Y
S
I
L
Q
Q
R
T
H
R
H
E
L
F
T
Frog
Xenopus laevis
NP_001083783
527
59670
T141
Y
T
I
L
Q
Q
R
T
H
R
H
E
L
F
T
Zebra Danio
Brachydanio rerio
NP_775353
527
59243
T141
Y
T
I
L
Q
Q
R
T
H
R
H
E
L
F
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647995
525
58740
L140
A
M
L
L
Q
K
T
L
R
H
D
L
F
A
P
Honey Bee
Apis mellifera
XP_001120791
454
52119
L93
K
F
I
L
E
N
I
L
P
D
L
Y
A
E
A
Nematode Worm
Caenorhab. elegans
Q19196
534
60979
S146
Q
R
A
M
R
C
A
S
L
K
N
F
K
F
T
Sea Urchin
Strong. purpuratus
XP_796825
501
56117
G132
G
A
S
N
E
T
Q
G
K
K
F
Q
L
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001147081
533
59891
L143
Y
R
D
R
Y
Q
V
L
L
Q
R
L
S
R
D
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P24482
689
78322
N242
F
Q
N
S
D
M
F
N
P
L
S
S
M
V
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
92.4
93.5
N.A.
90.1
90.8
N.A.
86.1
82.1
81
73.2
N.A.
42.1
39.2
30.8
57.6
Protein Similarity:
100
99.2
94.3
97.1
N.A.
94.8
95.2
N.A.
90.8
91.4
91
88
N.A.
59.7
58
51.1
75.7
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
86.6
93.3
93.3
N.A.
6.6
13.3
13.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
20
13.3
40
26.6
Percent
Protein Identity:
N.A.
36.2
N.A.
N.A.
24.3
N.A.
Protein Similarity:
N.A.
56.2
N.A.
N.A.
42.9
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
0
0
0
7
0
0
0
0
0
7
7
7
% A
% Cys:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
0
7
0
0
0
0
7
7
0
0
0
7
% D
% Glu:
0
0
0
0
13
0
0
0
0
0
0
63
0
7
0
% E
% Phe:
7
7
0
0
0
0
7
0
0
0
7
7
7
69
0
% F
% Gly:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
38
0
0
0
63
7
63
0
0
0
0
% H
% Ile:
0
0
69
0
0
0
7
0
0
0
0
0
0
0
0
% I
% Lys:
7
0
0
0
0
7
0
0
7
13
0
0
7
7
0
% K
% Leu:
0
0
7
75
0
0
0
19
13
7
7
13
69
0
0
% L
% Met:
0
7
0
7
0
7
0
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
7
7
0
7
0
7
0
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
13
% P
% Gln:
7
7
0
0
32
69
7
0
0
7
0
7
0
0
0
% Q
% Arg:
0
13
0
7
7
0
63
0
7
63
7
0
0
7
0
% R
% Ser:
0
7
7
7
0
0
0
7
0
0
7
7
7
0
7
% S
% Thr:
0
57
0
0
0
7
7
63
0
0
0
0
0
0
69
% T
% Val:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
69
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _